L-Glutathione – Health Benefits – Dosage – Studies

9. April 2017

What is L- Glutathione

Glutathione is a molecule consisting of three amino acids – glutamic acid – cysteine – glycine – that serves as a nutrient for many important processes within the body. L-glutathione functions include making proteins, building and repairing tissues, and aiding with the immune system by protecting against cell damage caused by free radicals, peroxides, and heavy metals.

Glutathione is a reaction produced naturally within the liver, and is also commonly found in many fruits, vegetables, and meats. However due to several factors such as aging, poor diet, stress, and trauma the body may not produce the needed quantities of glutathione to maintain optimum health. Recent studies have shown that taking additional glutathione supplements can lead towards a stronger immune system due to its immune-boosting properties.


What are the Health Benefits of L-Glutathione?

There are many benefits to using l-glutathione supplements as part of your daily lifestyle routine for maintaining a high glutathione Level in your body. Glutathione primarily functions by acting as an antioxidant [1], to help regulate iron metabolism [2], manage the oxidative stress, and aid in the progression of the cell cycle [3].

This helps maintain many body systems including the eyes, skin, and cardiovascular systems. [4] There are also many medicinal uses of l-glutathione which are currently being used to help treat many ailments and diseases today.


Immune Function

Due to its role in the synthesis of proteins, l-glutathione is most commonly used when fighting disease that weaken the body’s defense mechanisms.

Multiple Studies have shown that Patients with AIDS, Alzheimer ‘s and Parkinson’s disease were associated with glutathione deficiency. [5] [6] [7] [8].

One study conducted on autistic children found that their parents tend to share similar metabolic deficits including a decreased detoxification capacity and chronic oxidative stress.

Further studies are being conducted to determine if glutathione supplements can help aid in the cognitive functioning of autism in children. [9] As one of the major endogenous antioxidants a high level of glutathione improves immune function. [10] [11]



The idea of GSH (glutathione) may play an anti-inflammatory role in our body became popular in the 1990s by a study conduct in 1991 showing the antioxidant functions of glutathione.

Furthermore, it become clear that glutathione plays an essential role for some functions of the immune system and defense against infections. [12] [13]



Glutathione is also critical for detoxification in our body and works mainly in our liver.

Multiple cases have shown the detox power of glutathione. Studies have shown that high levels of GSH (glutathione) acts protective against mercury cytotoxicity [14] [15] side effects of alcoholism [16] and overdoses of analgesics such as paracetamol [17].

One study found that when repeated rounds glutathione were administered to ovarian cancer patients. it resulted in an improved life quality for ovarian cancer patients through decreased thoughts of depression, hair loss, and difficulty concentrating. [18]



The main advantage to glutathione is its ability to protect cells from damage in the body and infections. [19] [20] [21]

L-glutathione is one of the most studied antioxidants and has shown the reducing effect of oxidative stress such as after physical exercise [22]

In other words, the molecule’s antioxidant properties make it an attractive supplement to use in proactively health lifestyles and diets. Cancer risk has recently been hypothesized to correlate with selenium deficiency.

A 2011 study found that the oxidative stress-reliever component of glutathione supplements had a direct impact on selenium levels. [23]


Cognitive Health

Glutathione helps to slow the breakdown of nitric oxide and protect organs from ischemic damage, or a restriction of the blood supply to tissues. This can impact those with declined cognitive abilities due to disease or old age.

One study on a group of healthy women aged 60-103 years old were monitored over a 5-year period while taking glutathione supplements. Their results found that increased glutathione levels were in direct correlation with the top mental and physical health of older women. [24]

Furthermore, glutathione has important extracellular functions in the brain [25] such as defense against oxidation. [26] Free radicals and oxidative damage in brain cells is known to be a potential cause of degenerative diseases like Alzheimer’s disease.

Glutathione (GSH) precursors can prevent damage of brain cells induced by amyloid plaques in Alzheimer’s disease. [27]



How much L-Glutathione per day?

Taking 250-1,000mg of glutathione a day has shown to play a significant impact in increasing the levels bioavailability of glutathione in the body.

A six-month trial of healthy, non-smoking adults found that daily supplements reduced oxidative stress and increasing cytoxicity-fighting agents. [28]

However, after just one month of non-usage, glutathione levels returned to baseline making the diligent use of these supplements vital for increased immune functioning. [28]



What are the BEST and EASIEST ways to get L-Glutathione?

L-Glutathione Injection

Glutathione injections one of the direct and effective ways to enhance GSH levels in your body. Intravenous glutathione is often used for therapeutic uses such as Parkinson’s disease.

For most of the people an injection is not an option for regular use of glutathione.


L-Glutathione Supplementation

The most easiest way to take glutathione is orally through supplements, which has made an impact in treating patients with cataracts, asthma, hepatitis, high cholesterol and for detoxification.

There are many opinions about oral supplementation of glutathione. Multiple studies have shown that oral intake of glutathione, glutathione precursor such as n-acetyl-l-cysteine, glutamine can increase your GSH levels. [29] [30] [31] [32]

Even supplements such as omega-3 or vitamin d3 may increase your GSH levels.


L-Glutathione in Whey Protein

High quality whey protein has all the key amino acids for glutathione production. The amino acids cysteine, glycine and glutamine enhances GSH (glutathione) levels. [33]

Cold pressed whey protein derived from grass fed cows, and free of hormones, chemicals and sugar is a great choice.

10 Grams of Whey Protein twice daily can increase your glutathione level. [34]

Bulletproof Upgraded Whey Protein

L-Glutathione in Food

As mentioned, there are different ways to increase glutathione level in your body. Eating the right foods is one of them.

High protein food with all the key amino acids – glutamine – cysteine – glutamine.

FRESH fruits and vegetables can deliver the building blocks for glutathione. Especially food with high selenium or alpha lipoic acid.


Small Glutathione food list:

  • Eggs
  • Fish
  • Broccoli
  • Avocados
  • Garlic
  • Grapefruit
  • Spinach


Top Glutathione PRECURSOR you can buy


My favorite Glutathione Supplements


Glutathione FREE Infographic!

I have also created an infographic about Glutathione.

Glutathione Infographic

[1] https://www.ncbi.nlm.nih.gov/pubmed/14555227

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098478/

[3] https://www.ncbi.nlm.nih.gov/pubmed/10880854

[4] https://www.ncbi.nlm.nih.gov/pubmed/1913980


[5] https://www.ncbi.nlm.nih.gov/pubmed/1418777

[6] https://www.ncbi.nlm.nih.gov/pubmed/1418777

[7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640603/

[8] https://www.hindawi.com/journals/omcl/2016/9409363/

[9] https://www.ncbi.nlm.nih.gov/pubmed/18512136

[10] https://www.ncbi.nlm.nih.gov/pubmed/11115795

[11] https://www.ncbi.nlm.nih.gov/pubmed/18694818

[12] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048347/

[13] https://www.ncbi.nlm.nih.gov/pubmed/9616308


[14] https://www.ncbi.nlm.nih.gov/pubmed/2315960

[15] https://www.ncbi.nlm.nih.gov/pubmed/12495372

[16] https://www.ncbi.nlm.nih.gov/pubmed/17220370

[17] https://www.ncbi.nlm.nih.gov/pubmed/11941382

[18] https://www.ncbi.nlm.nih.gov/pubmed/9261526

[19] http://onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1977.tb11368.x/pdf

[20] https://www.ncbi.nlm.nih.gov/pubmed/26597719

[21] https://www.ncbi.nlm.nih.gov/pubmed/12654482

[22] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129149/

[23] https://www.ncbi.nlm.nih.gov/pubmed/21462082

[24] https://www.ncbi.nlm.nih.gov/pubmed/12486409

[25] https://www.ncbi.nlm.nih.gov/pubmed/12751781

[26] https://www.ncbi.nlm.nih.gov/pubmed/10880854

[27] The Journal of Cell Biology, Volume 164, Number 1, 123-131; 5 January 2004

[28] https://www.ncbi.nlm.nih.gov/pubmed/24791752

[29] https://www.ncbi.nlm.nih.gov/pubmed/1550859

[30] https://www.ncbi.nlm.nih.gov/pubmed/2221062

[31] https://www.ncbi.nlm.nih.gov/pubmed/1913980

[32] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536296/

[33] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905294/

[34] https://www.ncbi.nlm.nih.gov/pubmed/15463873

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Have you experience with Glutathione? Whats your opinion? Do you have any questions or critique? Feel free to comment below 😀